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KMID : 0361720130240040221
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Korean Journal of perinatology
2013 Volume.24 No. 4 p.221 ~ p.228
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Intestinal Microbiota in Preterm Infants and Probiotics Use for Disease Prevention
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Kim Eun-Sun
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Abstract
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Infectious complications such as necrotizing enterocolitis (NEC) or neonatal sepsis are main causes of mortality and disability in very low birth weight infants (VLBWIs). Because preterm infants are exposed to too unfavorable environment to promote appropriate intestinal colonization, pathologic organisms can easily colonize and host defense systems are also down-regulated in preterm gut, causing infectious complications such as NEC. To promote appropriate intestinal microbiota, probiotics have been studied for potential benefits by increasing mucosal barrier function, reducing intestinal pathogens, up-regulating immune system balancing inflammation. Large randomized controlled trials have shown favorable effects of probiotics on preterm NEC and mortality. Meta-analysis of clinical trials showed consistent evidence of probiotics uses in preterm infants. However, adequate type, dose, timing, and duration of probiotics have not been standardized for clinical applications. Inaddition, other interventions promoting preterm intestinal micobiota and immunity, such as prebiotics or lactoferrin, are on studies in combination with probiotics. More clinical trials should be added for the evidence based clinical use of probiotics in preterm infants.
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KEYWORD
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Probiotics, Preterm infants, Necrotizing enterocolitis, Mortality
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